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Image of Sheri Mizumori

Sheri Mizumori, Ph.D.

Professor

Interests: Neurobiological Mechanisms of Plasticity, Spatial Learning & Memory

Contact

Phone (206) 685-9660
E-mail mizumori@uw.edu
Website(s) Website

Advising

Do I accept and train new psychology graduate students in general?
Yes
Am I accepting new graduate students in the upcoming year?
I am NOT accepting graduate students in the 2019-2020
Advising Areas:
Behavioral Neuroscience

Research

Understanding the mechanisms of neuroplasticity as related to learning and memory is fundamental to our understanding of the causes of a variety of cognitive disorders as well as the developmental changes in learning that occur across the lifespan. Our laboratory attempts to address these issues by using a rodent model of spatial navigation to investigate the dynamic responses of single neurons in the brain, as well as the complex interactions between cells located in different memory-related structures. These studies employ techniques involving recording extracellular signals from many cells simultaneously as animals perform memory tasks. Our studies have examined many processes that contribute to successful and adaptive navigation: 1) the evaluation of sensory input during active locomotion, 2) the integration of current sensory information with past knowledge about an environment, and with internal state information, and 3) the behavioral implementation of highly processed spatial information. More recently, we have been considering these processes in terms of the flexibility of underlying neural representational systems during shifts in cognitive strategy or task demands. We are particularly interested in the role of neuromodulators such as dopamine in flexible memory function.

Selected Publications

  • Baker, P. M., Oh, S. E., Kidder, K. S., & Mizumori, S. J. Y. (2015). Ongoing behavioral state information signaled in the lateral habenula guides behavioral flexibility in freely moving rats. Frontiers in Behavioral Neuroscience, 9: 295. PMID: 26582981
  • Baker, P. M., Raynor, S. A., Francis, N. T., & Mizumori, S. J. Y. (2016). Lateral habenula integration of proactive and retroactive information mediates behavioral flexibility. Neuroscience, PMID 26876779
  • Eshenko, O., & Mizumori, S. J .Y. (2007). Memory influences on hippocampal and striatal neural codes: Effects of a shift between task rules. Neurobiology of Learning and Memory, 87, 495-509.
  • Fobbs, W. C., & Mizumori, S. J. Y. (2014). Cost-benefit decision circuitry: proposed modulatory role for acetylcholine. Progress in Molecular Biology and Translational Science. PMID: 24484704
  • Gill, K. M., & Mizumori, S. J. Y. (2006). Context-dependent modulation by D1-receptors: Differential effects in hippocampus and striatum. Behavioral Neuroscience, 120, 377-392.
  • Gill, K. M., & Mizumori, S. J. Y. (2008). Spatial learning and the selectivity of hippocampal place fields: Modulation by dopamine. In S. J. Y. Mizumori (Ed.) Hippocampal Place Fields: Relevance to Learning and Memory. Oxford Univ. Press, 271-288.
  • Gill, K. M., Bernstein, I. L., & Mizumori, S. J. Y. (2007) Immediate early gene activation in hippocampus and dorsal striatum: Effects of explicit place and response training. Neurobiology of Learning and Memory, 87, 583-596.
  • Gill, P. R., Mizumori, S. J. Y., & Smith, D. M. (2010). Hippocampal episode fields develop with learning. Hippocampus (in press).
  • Gill, P. R., Mizumori, S. J. Y., & Smith, D. M. (2011). Hippocampal Episode Fields Develop with Learning. Hippocampus, 21: 1240-1249. PMCID: PMC2970708
  • In J. L. Martinez, Jr. & R. P. Kesner (Eds.) Neurobiology of Learning and Memory
  • Jo, Y. S., & Mizumori, S. J. Y. (2015) Prefrontal regulation of neuronal activity in the ventral tegmental area. Cerebral Cortex , pii: bhv215. PMID: 26400913
  • Jo, Y. S., Lee, J., & Mizumori, S. J. Y. (2013). Effects of prefrontal cortical inactivation on neural activity in the ventral tegmental area. Journal of Neuroscience, 33: 8159-8171. PMCID: PMC3675177
  • Kim, M. J., Mizumori, S. J. Y., & Bernstein, I. L. (2010). Encoding conditioned taste by neurons in basolateral nucleus of amygdala of rats. Neurobiol. Learn. Mem., 93, 406-414.
  • Martig AK, Jones GL, Smith KE, and Mizumori SJ. (2009). Context dependent effects of ventral tegmental area inactivation on spatial working memory. Behavioural Brain Research 203, 316-20.
  • Martig, A. K. & Mizumori S. J. Y. (2010). Ventral tegmental area disruption selectively affects CA1/CA2 but not CA3 place fields during a differential reward working memory task. Hippocampus (in press)
  • Martig, A. K., & Mizumori, S. J. Y. (2011). Ventral tegmental area and substantia nigra neural correlates of spatial learning. Learning and Memory, 18: 260-271. PMID: 21447624
  • Martig, A. K., & Mizumori, S. J. Y. (2011). Ventral tegmental area disruption selectively affects CA1/CA2 but not CA3 place fields during a differential reward working memory task. Hippocampus, 21: 172-184. PMCID: PMC2988981
  • Mizumori , S. J. Y. (2015). Self regulation of memory processing centers of the brain. In P. Jackson, R. Berman, A. Chiba, & M. Ragozzino (Eds.) The Neurobiological Basis of Memory: A System, Attribute, and Process Analysis. Springer Press. In Press.
  • Mizumori S. Y. J. (2013). Context prediction analysis and episodic memory. Frontiers in Behavioral Neuroscience, 7: 132. PMCID: PMC3791547
  • Mizumori SJ, Puryear CB, and Martig AK. (2009). Basal Ganglia Contributions to Adaptive Navigation. (2009). Behavioural Brain Research 199, 32-42.
  • Mizumori, S. J. Y. (2006). Hippocampal place fields: A neural code for episodic memory? Hippocampus, 16, 685-690.
  • Mizumori, S. J. Y. (2008). A context for hippocampal place cells during learning. In S. J. Y. Mizumori (Ed.) Hippocampal Place Fields: Relevance to Learning and Memory. Oxford Univ. Press, 16-43
  • Mizumori, S. J. Y., & Jo, Y. S. (2013). Homeostatic regulation of memory systems and adaptive decisions. Hippocampus, 23: 1103-1124. PMID: 2392978.
  • Mizumori, S. J. Y., & Smith, D. M. (2006). Directing neural representations of space. In M. Brown and R. C. Cook (Eds.) Animal Spatial Cognition: Behavioral, Comparative & Computational Analyses. http://www.pigeon.psy.tufts.edu/asc/
  • Mizumori, S. J. Y., & Tryon, V. L. (2015). Integrative hippocampal and decision-making neurocircuitry during goal-relevant predictions and encoding. Progress in Brain Research, 219: 217-242. PMID: 26072241
  • Mizumori, S. J.Y., Smith, D. M., & Puryear, C. B. (2007). Hippocampal and neocortical interactions during context discrimination: Electrophysiological evidence from the rat. Hippocampus
  • Norton, A. B. W., Jo, Y. S., Clark, E. W., Taylor, C. A., & Mizumori, S. J. Y. (2011). Independent neural coding of reward and movement by pedunculopontine tegmental nucleus neurons in freely navigating rats. European Journal of Neuroscience, 33: 1885-1896. PMCID: PMC3095748
  • Penner, M. R., & Mizumori, S. J. Y. (2012). Age-associated changes in the hippocampal-ventral striatum-ventral tegmental loop that impact learning, prediction and context discrimination. Frontiers in Aging Neuroscience, 4: 1-12. PMID: 22891060
  • Penner, M. R., & Mizumori, S. J. Y. (2012). Neural systems analysis of decision making during goal-directed navigation. Progress in Neurobiology, 96: 96-135. PMID: 21964237
  • Puryear CB and Mizumori SJ. (2008). Reward prediction error signals by reticular formation neurons. (2008). Learning & Memory 15, 895-8.
  • Puryear, C. B., Kim, M. J., & Mizumori, S. J. Y. (2010). Conjunctive encoding of reward and movement by ventral tegmental area neurons: contextual control during adaptive spatial navigation Behavioral Neuroscience (in press)
  • Puryear, C. B., King, M., & Mizumori, S. J. Y. (2006). Specific changes in hippocampal spatial codes predict spatial working memory performance. Behavioural Brain Research, 169, 168-175.
  • Redila, V., Kinzel, C., Jo, Y. S., Puryear, C. B., & Mizumori, S. J. Y. (2015). A role for the lateral dorsal tegmentum in memory and decision neural circuitry. Neurobiology of Learning and Memory. 117:93-108. PMID: 24910282
  • Redish, A. D., & Mizumori, S. J. Y. (2015). Memory and decision making. Neurobiology of Learning and Memory, 117: 1-3. PMID:25192867
  • Smith, D. M., & Mizumori, S. J. Y. (2006). Hippocampal place cells, context and episodic memory. Hippocampus, 16, 716-729.
  • Smith, D. M., & Mizumori, S. J. Y. (2006). Learning-related development of context-specific neuronal responses to places and events: The hippocampal role in context processing. Journal of Neuroscience, 26, 3154-3163.
  • Smith, D. M., Barredo, J., & Mizumori, S. J. Y. (2011) Complimentary roles of the hippocampus and retrosplenial cortex in behavioral context discrimination. Hippocampus 22: 1121-1133. PMCID: PMC3166541
  • Zweifel LS, Parker JG, Lob CJ, Rainwater A, Wall VZ, Fadok JP, Darvas M, Kim MJ, Mizumori SJ, Paladini CA, Phillips PE, and Palmiter RD. (2009). Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior. Proceedings of the National Academy of Sciences of the United States of America 106, 7281-8.
  • Zweifel, L.S., Fadok, J.P., Argilli, E., Garelick, M.G., Jones, G.L., Dickerson, T.M., Allen, J.M., Mizumori, S.J., Bonci, A., & Palmiter, R.D. (2011). Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety. Nature Neuroscience, 14: 620-626. PMCID: PMC3083461

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